In humans, approximately 95% of multi-exon genes undergo alternative splicing. RNA splicing, a post-transcriptional process necessary to form a mature mRNA, was discovered in the late 1970s. The process of RNA splicing involves the removal of non-coding sequences or introns and joining of the coding sequences or exons. The human transcriptome is composed of a vast RNA population that undergoes further diversification by splicing. Detecting specific splice sites in this large sequence pool is the responsibility of the major and minor spliceosomes in collaboration with numerous splicing factors. Increased systematic sequencing of the genome and transcriptome of cancers has identified a variety of means by which RNA splicing is altered in cancer relative to normal cells. This complexity make … RNA splicing is a form of RNA processing in which a newly made precursor messenger RNA (mRNA) is transformed into a mature RNA by removing the non-coding sequences termed introns.. Recently, more and more studies focused on the relationship between AS and gastric cancer (GC). 1 Two different modes of splicing have been defined, that is, constitutive splicing and alternative splicing. We describe why splicing can be prone to errors with potentially pathological consequences, and then summarize mutations in both cis-acting RNA … RNA splicing, the enzymatic process of removing segments of premature RNA to produce mature RNA, is a key mediator of proteome diversity and regulator of gene expression. In this Review, we focus on RNA mis-splicing in disease, providing background information on splic-ing mechanisms in BOX 1. Alternative splicing (AS) linked to diseases, especially to tumors. It plays a critical role in the regulation of gene expression and protein diversity in a variety of eukaryotes. We highlight dysfunctional alternative splicing events that contribute to the aging phenotype across multiple species, along with recent efforts toward deciphering mechanistic roles for RNA splicing in the regulation of aging and longevity. Alternative splicing of RNA is a crucial process for changing the genomic instructions into functional proteins. This review surveyed the hot topic from four aspects: First, the common types of AS in cancer, including exon skipping, intron retention … During mRNA splicing in the spliceosome, protein factors and short conserved RNA sequences in the spliceosomal snRNAs collaborate to identify the intron 5′ splice site and the branch site. The emerging transcription–folding–splicing paradigm is changing our understanding of RNA alternative splicing regulation. Constitutive splicing is the process of removing introns from the pre-mRNA, and joining the exons together to form a mature mRNA. The branch site is a specific adenosine residue near the 3′ end of the intron that provides the 2′ OH nucleophile for the first trans-esterification reaction. Variability in splicing patterns is a major source of protein diversity from the genome. Abstract Alternative pre-mRNA splicing is a central mode of genetic regulation in higher eukaryotes. RNA Splicing Definition. This review focuses on recent research towards defining RNA splicing as a new hallmark of aging. Introduction. Precursor messenger RNA (pre-mRNA) splicing is an essential step in the flow of information from DNA to protein in all eukaryotes. In this review, I describe what is currently known of the molecular mechanisms that control changes in splice site choice. Additionally, we explore the recently FDA-approved small molecule regulator of RNA splicing, risdiplam, for treatment of spinal muscular atrophy. 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